Correction for “ Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in
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MEDICAL SCIENCES Correction for “Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers,” by Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, and Davide Ruggero, which appeared in issue 29, July 16, 2013, of Proc Natl Acad Sci USA (110:11988–11993; first published June 26, 2013; 10.1073/pnas.1310230110). The authors note that Fig. 5 appeared incorrectly. The corrected figure and its legend appear below.
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Correction for “ Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc - driven cancers
MEDICAL SCIENCES Correction for “Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers,” by Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, and Davide Ruggero, which appeared in issue 29, July 16, 2013, of Proc Natl Acad Sci USA (110:11988–11993; first published June 26, 2013; 10.107...
متن کاملMyc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers.
Myc is one of the most commonly deregulated oncogenes in human cancer, yet therapies directly targeting Myc hyperactivation are not presently available in the clinic. The evolutionarily conserved function of Myc in modulating protein synthesis control is critical to the Myc oncogenic program. Indeed, enhancing the protein synthesis capacity of cancer cells directly contributes to their survival...
متن کاملThe effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes
Introduction: The mTOR pathway in skeletal muscle plays a very important role in the protein synthesis process, which plays a very important role in proteins. The role of endurance exercise has not yet been studied in this important pathway in protein synthesis in people with type 2 diabetes. The purpose of the present study was to investigate the effect of 8 weeks endurance training on the con...
متن کاملTHE EFFECTS OF 4 WEEKS HIGH INTENSITY INTERVAL TRAINING ON MAMMALIAN RAPAMYCIN TARGET PROTEIN (MTOR) AND STEROL TRANSCRIPTION FACTOR REGULATORY PROTEIN-1 (SREBP1) PROTEINS CONTENT IN DIABETICS OBESE RATS ADIPOSE TISSUE
Background: Obesity and type 2 diabetes can impair the function of important cellular pathways. Activation of the mTOR pathway results in regulation of the SREBP1 protein for metabolism and regulation of adipose tissue. The aim of this study was to investigate the effect of 4 weeks of high intensity interval training on the content of mTOR and SREBP1 in adipose tissue of type 2 diabetic rats. ...
متن کاملTHE EFFECT OF 4 WEEKS’ AEROBIC TRAINING ON THE CONTENT OF MTORC1 SIGNALING PATHWAY PROTEINS IN HEART TISSUE OF TYPE 1 DIABETES RATS
Background: The mTORC1 pathway is one of the important pathways for protein synthesis in the heart, which can lead to physiological or pathological hypertrophy. Diabetes can lead to defects in this pathway. The aim of this study was to examine the effect of 4 weeks’ aerobic training on the content of mTORC1 signaling pathway proteins in heart tissue of type 1 diabetes rats. Methods: In this ...
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